The TNFRSF11B Antibody from MyBioSource.com is a Mouse Monoclonal antibody to osteoprotegerin, and TNFRSF11B. This antibody recognizes Human antigen. The TNFRSF11B Antibody has been validated for the following applications: ELISA, Flow Cytometry, Immunofluorescence, and Western Blot.
Description
Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined